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We determined the frequency of dementia in a cohort of 251 patients aged>/=60 years hospitalized with acute ischemic stroke,based on examinations performed 3 months after stroke onset.Using modified DSM-III- R criteria,we found dementia in 66 patients(26.3%).Diagnostic agreement among raters was excellent(kappa=0.96).In a control sample of 249 stroke- free subjects recruited from the community and matched by age,we found dementia in eight subjects(3.2%).Using a logistic regression model to estimate the risk of dementia associated with stroke in the combined samples,the odds ratio(OR)for stroke patients compared with control subjects was 9.4(p<0.001).Advancing age and fewer years of education were significant,independent correlates of dementia,with a trend evident for race(non-white versus white).Confining the analysis to subjects residing in the Washington Heights-Inwood community of northern Manhattan,the OR was 10.3(p<0.001)with significant age and race effects.We conclude that ischemic stroke significantly increases the risk of dementia,with independent contributions by age,education,and race. |
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